What is Monkeypox Virus? Monkeypox is a viral zoonotic disease caused by infection with monkeypox virus. Monkeypox virus is an enveloped double-stranded DNA virus from the Ortho-poxvirus genus in the family Poxviridae. It shares the same genus with the variola virus which causes smallpox, the vaccinia virus which was used for the development of smallpox...